Yes, it can be irritating, especially if you have sensitive skin. There are some gentler formulas on the market (for example Nicole, by OPI, is toluene free). Make sure to get some non-acetone polish remover, which can be more gentle than regular remover. Wash your hands with soap and water as soon as you nail polish is off, and that should keep your skin from being as irritated. Also, if you have hang nails or other already-irritated areas around your nails, hold off on the polishing until they heal up.
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